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Multiple stimuli-activated multimodal imaging. FHCPC@MnO2 nanoflowers were designed to exploit the low pH and high levels of GSH and H2O2 that exist in the TME for a) MR and b) FL imaging. A hybrid protein@inorganic nanodumpling (ND) system was designed to be activated by thiols, such as GSH, and low pH. Degradation of the nanosystem in the TME enabled activatable c) MR and d) FL imaging. Reproduced with permission.[86,88] Copyright 2019, RCS Pub and 2020, American Chemical Society.
