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GSH-activated multimodal imaging. a) NPs were self-assembled from a compound containing a 19F-MRS signal moiety, a Gd-DOTA chelate, and a disulfide-capped fluorophore. b) When incubated with GSH, the disulfide bond in the self-assembled NPs was cleaved. As a result, the disassembled NPs displayed activated FL (left), 19F-MR (middle), and T1-weighted MR (right) signals. Reproduced with permission.[41] Copyright 2016, American Chemical Society.
