. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: Eur J Drug Metab Pharmacokinet. 2021 Jan;46(1):105–118. doi: 10.1007/s13318-020-00653-1

Table 3.

Kinetic constants of the human SULT1E1 allozymes in catalyzing the sulfation of 4OH-tamoxifen

SULT1E1 allozyme	V_max (pmol/min/mg)	K_m (μM)	V_max/K_m (ml/min/mg)
SULT1E1-WT¹	907.20 ± 28.43	29.42 ± 3.17	0.031 ± 0.002
SULT1E1-A43D	178.90 ± 8.494^****	54 ± 8.18	0.003 ± 0.000^****
SULT1E1-A131P	944.05 ± 37.16	101.79 ± 10.90^****	0.009 ± 0.000^****
SULT1E1-R186L	324.80 ± 10.23^****	29.43 ± 6.93	0.011 ± 0.002^****
SULT1E1-P214T	770.25 ± 17.58***	56.18 ± 4.52	0.014 ± 0.000^****
SULT1E1-D220V	510.60 ± 42.01^****	144.80 ± 24.10^****	0.004 ± 0.000^****

Data shown represent mean ± SD derived from 3 independent experiments. One-way ANOVA was performed followed by Tukey’s post hoc analysis.

^****

Statistical significant p<0.0001 from SULT1E1-WT

Wild-type human SULT1E1