. Author manuscript; available in PMC: 2021 Jul 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2020 Oct 20;30(1):80–88. doi: 10.1158/1055-9965.EPI-20-0889

Table 3.

Standardized scoring coefficients for computing composite measures identified from factor analysis, Vermont DCIS Cohort.

	Factor 1	Factor 2	Factor 3	Factor 4	Factor 5
Total length	0.048	−0.143	0.195	0.117	0.482
Total minus end-to-end length	0.006	−0.026	0.489	0.005	0.092
^aStraightness	0.038	−0.087	−0.487	0.077	0.291
Width (μm)	−0.071	0.083	−0.141	−0.137	0.675
Distance to nearest 2 fibers	−0.244	−0.197	0.007	−0.190	0.025
^bBox density 24×24 μm	0.478	−0.139	0.011	0.051	−0.034
^bBox density 48×48 μm	0.158	0.270	−0.010	0.130	−0.035
^bBox density 96×96 μm	−0.055	0.424	0.001	0.043	0.058
Alignment of the nearest 4 fibers	0.004	0.103	−0.012	0.591	−0.220
^cBox alignment 24×24 μm	−0.424	0.226	0.007	0.236	−0.035
Distance to tumor/stromal boundary (μm)	−0.286	0.438	0.031	−0.162	−0.040
Angle relative to tumor/stromal boundary (°)	−0.046	0.052	0.023	−0.479	−0.119

Bold font is used to highlight collagen features with the highest coefficients (absolute value >0.4).

Straightness is defined as the ratio of the end-to-end length to the total length of the fiber.

Box density refers to the number of collagen fibers contained within a box of the specified size overlaid on the fiber centroid.

Alignment of fibers contained within a 24×24 μm box overlaid on the fiber centroid.