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. 2021 Jan 20;11:585082. doi: 10.3389/fendo.2020.585082

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Copyright © 2021 Cherait, Maucotel, Lefranc, Leprince and Vaudry

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of stroke and/or PACAP treatment on cumulative food intake and body weight variation. (A) Cumulative food intake after PACAP IN delivery over 3 h of time in non-operated mice. (B) Variation of body weight after PACAP administration following different stroke protocols, i.e., PACAP administration routes protocol (B1.), PACAP therapeutic window protocol (B2.), PACAP dose response efficiency protocol (B3.) and PACAP delayed IN daily administration efficiency protocol (B4.). Errors are reported as Mean ± S.E.M. (*P < 0.05; **P < 0.01; ***P < 0.001). Two-way ANOVA was performed for figure A and B4 showing significant means only for time factor (minutes and days), while the effects of treatment and the interaction are not significant.