Table 3.
Male baseline marijuana use frequency and spontaneous abortion among 1,535 PRESTO couples, stratified by attempt time at study entry (2013-2019)
| Marijuana use in the 2 months before baseline |
SABs | Gestational- Weeks of observation |
Median Gestational Weeks at Loss (IQR) |
Crude HR (95% CI) |
Adjusted HR (95% CI)a |
Adjusted HR (95% CI)b |
|---|---|---|---|---|---|---|
| Attempt Time <3 cycles (n=1,045 couples) | ||||||
| None | 146 | 11,280 | 6 (5-9) | REF | REF | REF |
| <1 time/week | 18 | 1,547 | 5 (5-7) | 1.1 (0.69-1.8) | 1.5 (0.87-2.7) | 1.5 (0.86-2.7) |
| ≥1 time/week | 20 | 1,050 | 5 (5-8) | 1.7 (1.1-2.8) | 2.1 (1.1-3.9) | 2.0 (1.1-3.9) |
| Attempt Time ≥3 cycles (n=490 couples) | ||||||
| None | 88 | 4,989 | 6 (5-9) | REF | REF | REF |
| <1 time/week | 4 | 560 | 5 (5-7) | 0.41 (0.15-1.1) | 0.43 (0.14-1.4) | 0.40 (0.13-1.3) |
| ≥1 time/week | 16 | 567 | 6.5 (5-9.5) | 1.6 (0.93-2.7) | 3.4 (1.5-7.7) | 3.7 (1.6-8.3) |
Gestational-weeks is the length of time pregnant until SAB or censoring. Gestational-weeks of observation is the number of weeks from detected pregnancy (i.e. entry into cohort) until SAB or censoring. SAB: spontaneous abortion; HR: Hazard Ratio; CI: Confidence Interval.
Adjusted for male and female: age, education, race/ethnicity, alcohol frequency, smoking status, environmental tobacco exposure, caffeine intake, sugar-sweetened beverage intake, BMI, weekly exercise, multivitamin use, hours work per week, history of STIs, depression/anxiety; male only: household income, hours of sleep per night, perceived stress scale; and female only: marijuana use frequency.
Additionally adjusted for reproductive history: female parity and history of spontaneous abortion, and male ever impregnated someone.