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. Author manuscript; available in PMC: 2022 Jan 18.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Nov 18;60(3):1220–1226. doi: 10.1002/anie.202008625

Figure 1.

Figure 1.

(A) Representative BET bromodomain inhibitors and (B) the sequence similarity in each bromodomain relative to BRD4 D1. Percent similarities relative to BRD4 D1 calculated by PDB Sequence & Structure Alignment. (C) Co-crystal structures of BRD4 D1 with (+)-JQ1, 1, and 6. Structured waters are shown in red (PDB ID: 3MXF, 6MH1, 6WGX).