(A) Average weekly energy intake in kilocalories consumed per week (B) Oxygen consumption in milliliters per minute per kilogram body weight post 15 weeks of respective diet feeding (C) Systolic Blood Pressure post 15 weeks of respective diet feeding (n=5-8 per group); CD, Control diet; HFD, High fat diet; DOX, Doxycycline; SOLA, 20-HETE antagonist; *p<0.05, **P<0.01, ***p<0.001, ****p<0.0001 using two-way ANOVA with post-hoc Tukey’s test.