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. Author manuscript; available in PMC: 2021 Feb 24.
Published in final edited form as: Pediatr Diabetes. 2020 Aug 9;21(7):1202–1209. doi: 10.1111/pedi.13085

FIGURE 1.

FIGURE 1

Study design for identifying metabolite-related nutrient patterns associated with progression from islet autoimmunity (IA) to T1D. A, We conducted a metabolome-wide association study to identify seroconversion lipidomics and metabolomics associated with progression to T1D by December 2018. Significant metabolites and nutrient patterns that best summarized them were identified using reduced rank regression. Metabolite-related nutrient pattern scores were tested for the risk of T1D. B, Of the 213 IA cases identified in DAISY by January 2015, 132 had untargeted metabolomics measures and dietary intake available at the time of seroconversion. DAISY, Diabetes Autoimmunity Study in the Young; T1D, type 1 diabetes