Presented as the unadjusted within group changes, 12-week changes for citrate synthase (A), cytochrome c oxidase (COX) activity (B), lesion frequency (C), and MtDNA (D). Data indicate unadjusted mean ± SE. Abbreviations: EX0 = exercise + placebo, EX500 = exercise + 500 mg/d resveratrol, EX1000 = exercise + 1,000 mg/d resveratrol.