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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Nitric Oxide. 2020 Nov 30;107:11–18. doi: 10.1016/j.niox.2020.11.005

Figure 8.

Figure 8.

Revised Hypothesis Figure. The effect of treatments on platelet activity depend on the amount of NO made. In the case of nitrite alone, sufficient NO is made so that platelet activation is inhibited. When light alone is applied, the amount of NO made will depend on how much is already bound to the RBCs from previous nitrite bioactivation. When this amount is small, platelet activation is not inhibited and may even be stimulated. For the cases where the nitrite and light is combined, NO formation is maximal and platelet activation is inhibited.