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. Author manuscript; available in PMC: 2022 Jan 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2020 Dec 3;411:115362. doi: 10.1016/j.taap.2020.115362

Figure 1.

Figure 1.

MMA+3 and UA produce opposing effects on PARP-1 activity in mouse thymus cells. Mouse thymus cells were exposed in vitro to MMA+3or UA for 18 h and PARP-1 activity was measured using the mouse PARP/Apoptosis ELISA kit from R&D Systems. (A) Inhibition of PARP-1 activity caused by exposure to 0, 50, 100, and 500 nM MMA+3. (B) Increased PARP-1 activity produced by exposure to 0, 0.5, 5, and 50 μM UA UA. Data are presented as mean ± SD. *Statistically significant difference (p<0.05) in one-way ANOVA followed by a Dunnett’s t-test compared to the control group.