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. 2021 Jan 20;10:600298. doi: 10.3389/fonc.2020.600298

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Copyright © 2021 Kwan, Xu, Gong, Bian and Chu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biodistribution of GA as a function of time in a variety of tissues in the HCC1806-bearing xenograft mouse models after free GA or GA-loaded FA-Arg-PEUU-NP (NP-GA) treatments. (A) 15 min, (B) 30 min, (C) 1h, (D) 2h, and (E) 4h after intravenous injection of free GA or GA-loaded FA-Arg-PEUU-NP (NP-GA) at the indicated dosage. The data are shown as the means ± SEM, n = 3 mice in each group. *p < 0.05, **p < 0.01 compared to 4mg-free-GA group; a < 0.05, aa < 0.01 compared to 8mg-free-GA group.