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. 2021 Jan 20;10:600298. doi: 10.3389/fonc.2020.600298

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Copyright © 2021 Kwan, Xu, Gong, Bian and Chu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polarization of tumor-associated macrophage (TAM) of the HCC1806-bearing xenograft mouse models after saline, FA-Arg-PEUU-NP (NP), free GA, or GA-loaded FA-Arg-PEUU-NP (NP-GA) treatments. (A) The polarization of the tumor-associated macrophages (TAM) of the HCC1806-bearing xenograft mouse models after the saline, FA-Arg-PEUU-NP (NP), free GA, or GA-loaded FA-Arg-PEUU-NP (NP-GA) treatments. The percentages of the (B) M1 phenotype, (C) M2 phenotype, and (D) M1/M2 ratio of the TAM. The data are shown as the means ± SEM, n = 5 mice in each group. *p < 0.05 as indicated.