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. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: Toxicology. 2020 Dec 24;449:152662. doi: 10.1016/j.tox.2020.152662

Figure 5. MPCCs maintained in physiologic medium are useful for drug-induced hepatotoxicity and CYP induction testing.

Figure 5.

MPCCs were cultured in physiologic medium for 10 days and then treated with prototypical drugs. (a) Urea synthesis from MPCCs treated with (a) hepatotoxic or (b) non-hepatotoxic drugs for 5 days. Induction of (c) CYP3A4, (d) CYP1A2, and (e) CYP2C9 enzymes following treatment with indicated prototypical drugs or DMSO control (0.1% v/v) for 4 days. Error bars represent SD.