Table 4:

Accuracy with shorter (≤3.9 years) and longer (>3.9 years) PET-to-autopsy time interval

PET to autopsy interval	Shorter (≤3.9Y) n=50, 17 I/H ADNC			Longer (>3.9Y) n=51, 28 I/H ADNC
	PIB	FDG	P	PIB	FDG	P
Sensitivity	94 [71–100]	88 [64–99]	0.56	96 [82–100]	75 [55–89]	0.01
Specificity	85 [68–96]	78 [60–91]	0.32	87 [66–97]	92 [73–99]	0.65
Positive Likelihood Ratio	6.2 [2.8–14.1]	4.0 [2.1–7.9]	0.28	7.4 [2.6–21.3]	9 [2.4–34.5]	0.61
Negative Likelihood Ratio	0.07 [0.01–0.45]	0.15 [0.04–0.56]	0.51	0.04 [0.01–0.3]	0.27 [0.14–0.52]	0.04
Positive Predictive Value	76 [53–92]	68 [45–86]	0.27	90 [73–98]	91 [72–99]	0.87
Negative Predictive Value	97 [82–100]	93 [76–99]	0.51	95 [76–100]	76 [56–90]	0.01
Accuracy	88 [76–95]	82 [68–91]	0.77	92 [80–98]	83 [68–91]	0.04

Abbreviations: PIB – ¹¹C- Pittsburgh compound B; FDG – ¹⁸F fluorodeoxyglucose; AD – Alzheimer’s disease; I/H – Intermediate/High; ADNC – Alzheimer’s disease neuropathological changes