Table 1:
Clinical history for pancreatitis and diabetes for each case
| Case | AP | CP | Age (y) AP or CP Dx | Age (y) T1D Dx | Genetic Risk Factors* | Pancreas Surgery | Age (y) Pancreas Surgery | Insulitis by Biopsy | GAD Ab | Insulin Ab | Islet Cell Ab | IA-2 Ab | ZnT8 Ab | C-peptide fasting/stimulated (ng/mL)* | Duration T1D at C-peptide (months) | HbAlc range (%) | Current insulin regimen |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Suspected | Yes | 43 | 46 | N/A | TPIAT | 46 | No | + | - | - | - | ND | 0.1/0.1 | 13 | 5.4 – 8.3 | insulin pump |
| 2 | Yes | Yes | 13 | 9 | N/A | TP without IAT | 15 | No | + | + | ND | ND | 0.1/0.1** | 68 | 7.8 – 10.6 | insulin pump | |
| 3 | Yes | Yes | 10 | 15 | N/A | TPIAT | 17 | Yes | + | + | + | + | - | 0.1/0.1 | 41 | 5.1 – 6.9 | insulin pump |
| 4 | Yes | No | 13 | 14 | PRSS1 (R122H) | None | N/A | + | + | + | ND | ND | ND | 5.3 – 10.3 | insulin pump | ||
| 5 | Yes | Yes | 9 | 16 | N/A | TPIAT | 15 | No | + | + | - | ND | ND | 0.2/0.7 | 19 | 4.8 – 9.3 | insulin pump |
| 6 | Yes | Yes | 2 | 7 | PRSS1 (R122H) + CFTR (R75Q) | TPIAT | 7 | Yes | + | + | 0.1/0.1 | 3 | 5.0 – 8.4 | insulin pump | |||
| 7 | Yes | Yes | 1 | 10 | PRSS1 (R122H) | TP without IAT | 12 | No | + | + | + | ND | ND | 7.1 – 8.5 | insulin pump | ||
| 8 | Yes | Yes | 37 | 44 | N/A | TPIAT | 43 | No | + | + | 0.1/0.1 | 8 | 5.2 – 12.8 | MDI | |||
| 9 | Suspected | No | 33 | 33 | PRSS1 (R122H) | None | N/A | + | + | + | ND | ND | 5.9 – 9.9 | MDI | |||
| 10 | Yes | Yes | 27 | 30 | CFTR ((TG)12-5T variant) | TPIAT | 30 | No | + | + | + | ND | 0.1/0.3 | 6 | 4.6 – 9.2 | insulin pump | |
| 11 | Yes | Yes | 1 | 4 | PRSS1 (R122H) | TPIAT | 4 | Yes | + | + | - | - | - | 0.6/2.0 | 12 | 5.1 – 6.4 | insulin pump |
AP=acute pancreatitis, CP= chronic pancreatitis, T1D = type 1 diabetes mellitus, Dx=diagnosis; GAD = Glutamic Acid Decarboxylase; IA-2 = islet tyrosine phosphatase 2; ZnT8= zinc transporter 8; MDI= multiple daily injections; TPIAT= total pancreatectomy and islet autotransplant; N/A = not applicable; ND= not done
+
indicates genetic risk factors for pancreatitis
*
fasting and stimulated C-peptide value by Boost HP meal (6 mL/kg to maximum 360 mL), most recent result
**
C-peptide level before total pancreatectomy without islets.