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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Metabolism. 2020 Dec 1;116:154457. doi: 10.1016/j.metabol.2020.154457

Table 2.

Summary of structurally specific BAs showing significant associations with NAFLD histology phenotypes

Fibrosis NASH Inflammation Ballooning
GCA 7-Keto-DCA GCA 7-Keto-DCA
GCDCA 7-Keto-LCA TCA Iso-DCA
7-Keto-DCA GCDCA 7-Keto-LCA
GUDCA TCDCA Iso-LCA

A panel of structurally specific BAs were quantified in the plasma of serial consenting subjects undergoing elective diagnostic liver biopsy for suspected NAFLD / NASH as described under Methods. Shown are those BAs whose circulating levels showed significant associations with one or more histopathological features of NAFLD/NASH. NASH: Non-Alcoholic Steatohepatitis; GCA: glycocholic acid; GCDCA: glycochenodeoxycholic acid; 7-Keto-DCA: 7-Ketodeoxycholic acid; GUDCA: glycoursodeoxycholic acid; 7-Keto-LCA: 7-Ketolithocholic acid; TCA: taurocholic acid; TCDCA: taurochenodeoxycholic acid; Iso-DCA: isodeoxycholic acid; Iso-LCA: isolithocholic acid