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. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: Neuropharmacology. 2020 Nov 18;184:108408. doi: 10.1016/j.neuropharm.2020.108408

Fig. 1. Dose-response effects of 5-HT on RMP, AP threshold, DSFs, and OA.

Fig. 1.

DRG neurons were treated with 5-HT or vehicle before and during recording. Each concentration is represented by a minimum of 8 cells from at least 2 rats. P values listed under overall significance indicate the result of ANOVA, Kruskal-Wallis, or Fisher’s exact tests assessing the presence of an overall effect across all doses. (A) 5-HT effects on RMP and AP threshold. Mean ± SEM. * Dunnett’s adjusted p value < 0.05. (B) 5-HT effects on the frequency of medium-amplitude (3–5 mV) and large-amplitude (>5 mV) DSFs during 30-s depolarization to −45 mV. Mean ± SEM. * Dunn’s adjusted p value < 0.05, ** p < 0.01. (C) 5-HT effects on the incidence of OA measured during a ≥ 60-s recording at RMP and then during a 30-s depolarization to −45 mV. P values indicate the result of Fisher’s exact tests comparing no 5-HT to all 5-HT concentrations combined. * p < 0.0083 (after Bonferroni correction for 6 comparisons). (D) 5-HT effects on rheobase. Mean ± SEM. Kruskal-Wallis test revealed a significant overall difference, but Dunn’s test did not reveal differences at individual doses.