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. Author manuscript; available in PMC: 2022 Feb 15.
Published in final edited form as: Neuropharmacology. 2020 Nov 18;184:108408. doi: 10.1016/j.neuropharm.2020.108408

Figure 7. Activation of cAMP signaling by the cAMP analog 8-Br-cAMP is sufficient to potentiate DSFs and OA in isolated DRG neurons.

Figure 7.

Patch pipettes contained 100 μM 8-Br-cAMP or vehicle in the ICS. (A) Effect of 8-Br-cAMP on the incidence of OA. The occurrence of OA was measured during ≥60-s recording at RMP then during 30-s depolarization to −45 mV. * p < 0.05. (B-E) Effect of 8-Br-cAMP on the frequency of medium- (3–5 mV) and large-amplitude (>5 mV) DSFs during 30-s depolarization to −45 mV (B), AP threshold (C), rheobase (D), and RMP (E). Mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.