Table 4.

Metabolic pathways associated with systolic (SBP) or diastolic blood pressure (DBP)

Metabolic pathways		SBP				DBP
	m*	k*	Enrichment score*	p-value†	q-value†	k*	Enrichment score*	p-value†	q-value†
Corticosteroids	6	0	--	--	--	3	12.47	0.001	0.005
Diacylglycerol	3	2	18.77	0.004	0.019	0	--	--	--
Fatty Acid Metabolism (Acyl Carnitine, Long Chain Saturated)	6	3	14.48	9E-04	0.009	3	12.47	0.001	0.005
Fatty Acid Metabolism (Acyl Carnitine, Medium Chain)	6	1	4.54	0.206	0.301	4	17.10	4E-05	3E-04
Monoacylglycerol	14	1	1.93	0.418	0.496	5	9.35	0.0002	0.001
Phosphatidylcholine (PC)	18	4	6.56	0.004	0.019	2	2.66	0.180	0.337
Phosphatidylinositol (PI)	5	2	11.24	0.013	0.049	2	9.72	0.017	0.048
Sphingomyelins	28	8	9.63	3E-06	6E-05	8	8.07	1E-05	2E-04

^*Enrichment score was calculated using (k/m)/[(n-k)/(N-m)], where k and n are numbers of BP-associated metabolites (Model 1 false discovery rate adjusted p-value<0.05) in a given pathway and all identified pathways (SBP: n=34; DBP: n=39), respectively; m and N are numbers of classified metabolites in a given pathway and all identified pathways(N=904), respectively.

^†P-value for each pathway was calculated using Fisher’s exact test and adjusted for false discovery rate (q-value) across pathways containing at least one BP-associated metabolite.