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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Biochim Biophys Acta Biomembr. 2020 Dec 17;1863(3):183533. doi: 10.1016/j.bbamem.2020.183533

Figure 3: Trends in detergents used for membrane protein solubilization.

Figure 3:

A) Year-by-year analysis of detergent classes used for solubilization of membrane proteins with unique structures solved between 2010 and 2019. B) Analysis of solubilization detergents used for unique membrane protein structures solved by either single-particle cryo-EM, LCP, vapor diffusion (VD), or NMR from 2010 to 2019. C) Comparison of detergents used to solubilize prokaryotic and eukaryotic membrane proteins with unique structures from 2010-2019. For each analysis, detergents were classified as outlined in Table 1 and the least commonly used detergents were collapsed into an “other” category which represented coverage of no more than 10% of proteins analyzed.