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. Author manuscript; available in PMC: 2022 Jan 12.
Published in final edited form as: Immunity. 2020 Nov 20;54(1):151–163.e6. doi: 10.1016/j.immuni.2020.10.014

Figure 2. IL-33-ST2 signal regulates gut motility.

Figure 2.

(A) WT mice were treated daily with IL-33 or PBS for 7 days. Colonic transit time was assessed by bead expulsion assay.

(B) Colonic transit time was measured by bead expulsion assay in WT, Il33−/− and Il1rl1−/− mice.

(C) Representative trace and (D) Quantification of colon contraction in WT, Il33−/− and Il1rl1−/− mice.

(E) WT, Il33−/− and Il1rl1−/− mice were treated daily with PBS or IL-33 for 7 days. Colonic transit time was assessed by bead expulsion assay at day 8.

(F) WT, Il33−/− and Il1rl1−/− mice were treated with PBS or IL-33, and waited for 10 minutes. Colonic transit time measured by bead expulsion assay.

(G) Representative trace of IL-33-induced colon contraction in WT, Il33−/− and Il1rl1−/− mice.

Data are representative of three independent experiments (C, G) or are pooled from two independent experiments (A, B, D-F). NS, not significant; *p < 0.05 (Student’s t-test, error bars represent SD). Please also see Figure S2.