Table 2.
Top 50 down-modulated genes in vitD3-Tcell compared to mDC-Tcell.
| GeneSymbol | GO annotation | FC vs mDC-Tcell | padj |
|---|---|---|---|
| IL13 | Cytokine | −2.59 | 0.00082 |
| C1orf106 | NA | −2.43 | 0.00486 |
| RYR2 | Ligand-Gated Ion Channel | −2.35 | 0.00802 |
| HLA-DQA2 | Major Histocompatibility Complex Antigen | −2.25 | 0.03271 |
| UBE2C | NA | −2.23 | 0.00000 |
| DEPDC1 | Nucleic Acid Binding | −2.23 | 0.00367 |
| NEK2 | Protein Kinase | −2.20 | 0.00206 |
| EBI3 | Cytokine; Defense/Immunity Protein | −2.18 | 0.00009 |
| CCL17 | Chemokine | −2.18 | 0.01852 |
| AURKB | Non-Receptor Serine/Threonine Protein Kinase | −2.14 | 0.00006 |
| CYP1B1 | Oxygenase | −2.12 | 0.02334 |
| SPC25 | Enzyme Modulator | −2.11 | 0.01556 |
| KIF4A | Microtubule Binding Motor Protein | −2.09 | 0.00001 |
| KIF18B | Microtubule Binding Motor Protein | −2.07 | 0.00001 |
| CCNB2 | Kinase Activator | −2.06 | 0.00000 |
| HLA-DRB5 | Major Histocompatibility Complex Antigen | −2.02 | 0.00970 |
| MCM10 | NA | −2.01 | 0.00003 |
| HIST1H3C | Histone | −2.01 | 0.00000 |
| KIF15 | Microtubule Binding Motor Protein | −1.97 | 0.00000 |
| BIRC5 | Protease Inhibitor | −1.96 | 0.00002 |
| CHST3 | NA | −1.95 | 0.01782 |
| FAM111B | NA | −1.95 | 0.00000 |
| MYBL2 | NA | −1.92 | 0.00000 |
| ATP8B4 | Cation Transporter. Hydrolase | −1.92 | 0.00000 |
| SKA1 | NA | −1.91 | 0.00898 |
| KIAA0101 | NA | −1.91 | 0.00292 |
| TK1 | Nucleotide Kinase | −1.90 | 0.00001 |
| HIST1H3J | Nucleic Acid Binding; Transcription Factor | −1.89 | 0.03504 |
| E2F8 | Nucleic Acid Binding; Transcription Factor | −1.89 | 0.00209 |
| HLA-DQA1 | Major Histocompatibility Complex Antigen | −1.88 | 0.00011 |
| HIST1H3F | Reductase | −1.88 | 0.00005 |
| RRM2 | Reductase | −1.88 | 0.00337 |
| GNG4 | Heterotrimeric G-Protein | −1.87 | 0.01479 |
| PRR11 | NA | −1.86 | 0.00041 |
| CEP55 | NA | −1.85 | 0.00008 |
| CKAP2L | NA | −1.84 | 0.00151 |
| CDCA8 | NA | −1.84 | 0.00015 |
| HIST1H3G | Histone | −1.83 | 0.00000 |
| CDK1 | Non-Receptor Serine/Threonine Protein Kinase; Non-Receptor Tyrosine Protein Kinase | −1.83 | 0.00283 |
| HMMR | NA | −1.83 | 0.00012 |
| PKMYT1 | Non-Receptor Serine/Threonine Protein Kinase | −1.83 | 0.00825 |
| CCL22 | Chemokine | −1.82 | 0.02508 |
| CREB3L3 | NA | −1.81 | 0.02749 |
| CDC25A | Protein Phosphatase | −1.81 | 0.02454 |
| DTL | NA | −1.81 | 0.00008 |
| RAD51AP1 | NA | −1.80 | 0.00912 |
| ESCO2 | NA | −1.79 | 0.01020 |
| LIF | Cytokine | −1.78 | 0.00000 |
| KIFC1 | Microtubule Binding Motor Protein | −1.78 | 0.00000 |
| ASB2 | NA | −1.78 | 0.00000 |
Gene expression values from an RNA-seq analysis with healthy donors (n = 10). Data presented as the mean fold change (FC) of expression in vitD3-Tcell compared to mDC-Tcell. GO, Gene Ontology; mDC-Tcell, mature dendritic cell-conditioned CD3+CD4+ cells; NA, not available; padj, adjusted p-value; vitD3-Tcell, vitamin D3-induced tolerogenic dendritic cell-conditioned CD3+CD4+ cells.