Table 5.

Adverse reactions to treatment and subsequent dosage adjustment

Adverse effects	N (%)	Dosage reduction	Discontinuation
Musculoskeletal	2 (6%)	0	0
Myalgia	1 (3%)	0	0
Arthralgia	1 (3%)	0	0
General	2 (6%)	0	0
Tiredness	1 (3%)	0	0
Fatigue	1 (3%)	0	0
Gastrointestinal	19 (61%)	4 (13%)	7 (23%)
Non-specific gastrointestinal disturbances	6 (19%)	0	1 (3%)
Dyspepsia	1 (3%)	0	0
Aerophagy	1 (3%)	0	0
Abdominal pain	6 (19%)	2 (6%)	3 (10%)
Nausea	9 (29%)	2 (6%)	6 (19%)
Vomiting	3 (10%)	0	3 (10%)
Diarrhoea	4 (13%)	3 (10%)	1 (3%)
Constipation	1 (3%)	1 (3%)	0
Heartburn	1 (3%)	1 (3%)	0
Cutaneous	5 (16%)	0	2 (6%)
Phototoxicity	3 (10%)	0	1 (3%)
Exanthema	1 (3%)	0	1 (3%)
Pruritus	1 (3%)	0	0
Psychiatric	2 (6%)	0	0
Insomnia	1 (3%)	0	0
Moodiness	1 (3%)	0	0
Central nervous system	2 (6%)	1 (3%)	0
Headache	1 (3%)	0	0
Dizziness	1 (3%)	1 (3%)	0