Fig 1. Intermittent fasting (IF) in high-capacity runners (HCR) and low-capacity runners (LCR).
(A) 14 weeks of IF induced significant weight loss in female rats, but this was more pronounced in LCR. (B) Body weight fluctuated day-to-day with food intake; the overall loss of body weight was significantly higher in LCR when considering weight on the day of food availability, the fasting day, or the average of these. (C) Ad libitum fed female HCR and LCR from the same cohort showed no weight loss over the same period. (D) There was a phenotypic difference in caloric intake where food intake on fed days was higher in HCR for the first 6 weeks of IF, but then did not differ between phenotypes by week 6 of IF. (E) Water intake mirrored food intake, where rats drank more water on fasted days, with no difference between HCR and LCR. *HCR ≠LCR, p<0.05, †significant interaction where LCR (n=8) lost more weight than HCR (n=8), p<0.05. Inset bar graphs show ad libitum-fed baseline, mean of all fed days, and mean of all fasting days; *p<0.05, 2-tailed t-test, HCR vs. LCR.