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. Author manuscript; available in PMC: 2021 Jul 18.
Published in final edited form as: Nat Metab. 2021 Jan 18;3(1):33–42. doi: 10.1038/s42255-020-00334-y

Extended Data Fig. 4. Extended Data 4. Mitochondrial mutant cells have basally elevated cytokines under nutrient stress conditions which are suppressed by doxycycline.

Extended Data Fig. 4

a. Gene expression of inflammatory cytokine panel under high-glucose conditions for control (CON), ND1, and MELAS cybrid cells (n=3 biologically independent samples). b. Gene expression of inflammatory cytokines in MELAS cybrid cells after 24 hour low-glucose (LG) conditions (n=6 biologically independent samples). c. Gene expression of inflammatory cytokines in ND1 cybrid cells after 48 hours galactose (GAL) conditions (n=3 biologically independent samples). Tetracycline analogs that rescue cell survival such as doxycycline, 7015, 7039, and 7066 suppress inflammatory gene expression. Data are presented as mean values +/− s.e.m. error bars, Student’s t-test with a two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli, with Q = 5%, * q<0.05.