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. Author manuscript; available in PMC: 2021 Jul 18.
Published in final edited form as: Nat Metab. 2021 Jan 18;3(1):33–42. doi: 10.1038/s42255-020-00334-y

Extended Data Fig. 5. Extended Data 5. Doxycycline suppresses inflammatory gene expression and metabolite levels in a time-dependent manner.

Extended Data Fig. 5

a. Heatmap of metabolites in ND1 cybrid cells that significantly change with doxycycline and 7066 compared to DMSO, 7004, 7013, and CMT-3 (n=3 biologically independent samples, p<0.05, Student’s t-test with Bonferroni’s correction). b. Time-dependent gene expression of inflammatory markers in ND1 cybrid cells under galactose conditions (n=3 biologically independent samples). c. Time-dependent metabolite changes in ND1 cybrid cells under galactose conditions (n=3 biologically independent samples). Data are presented as mean values +/− s.e.m. error bars, Student’s t-test with a two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli, with Q = 5%, * q<0.05.