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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Cell Signal. 2020 Dec 16;79:109888. doi: 10.1016/j.cellsig.2020.109888

Figure 2: Models of Cardiac Fibroblast State Transitions.

Figure 2:

A) Differential Fibroblast Injury Response in Myocardial Infarction and Angiotensin-Infusion Injury Models. Recent RNAseq studies suggest that fibroblasts state transitions vary based on the injury stimulus. This figure summarizes what is known about fibroblast transdifferentiation in response to myocardial infarction and angiotensin II infusion, but also illustrates unknowns regarding: the proliferation phase in an Angiotensin model, the genotype (SCA1 high or low) of resident fibroblast population that transitions to a myofibroblast identity, and SCA1 expression as fibroblast undergo state transitions. B) State Space Modulation of Myofibroblast Identity. Perturbing genes in the fibrotic pathway can alter the fibroblast state space landscape, changing the number of α-SMA expressing myofibroblasts. Illustrations represent several hypothetical outcomes from fibroblast state space modulation.