Table 1: Summary of pre-clinical and clinical studies on P38 and YAP inhibitors.

The p38 inhibitors summarized here are all from studies within cardiac systems, whereas the YAP inhibitors are from a mix of renal, hepatic, and pulmonary systems.

Paper/ Clinical Trial	Therapeutic(s)	Species	Injury Model	Result
Kyoi et al., 2006 [74]	SB203580* FR167653*	Hamster	Dilated Cardiomyopathy	Decreased cardiac fibrosis, myocyte death, dilation, and hypertrophy.
See et al., 2004 [75]	RWJ-67657*	Rat	Myocardial Infarction	Improved systolic function; decreased dilation, αSMA protein expression, and collagen I deposition; enhanced myocyte hypertrophy.
Yamagami et al., 2015 [76]	Pirfenidone*	Mouse	Pressure Overload	Improved systolic function; decreased dilation and interstitial fibrosis.
Nguyen et al., 2010 [77]	Pirfenidone*	Rat	Myocardial Infarction	Improved systolic function; decreased fibrosis; decreased frequency of ventricular tachycardia; decreased fibrosis in the infarct zone, border zone, and non-infarct area of the heart.
Wang et al., 2013 [78]	Pirfenidone*	Mouse	Pressure Overload	Decreased mortality and cardiac fibrosis.
Yamazaki et al., 2012 [79]	Pirfenidone*	Mouse	Angiotensin II	Decreased hypertrophy and cardiac interstitial and perivascular fibrosis.
Newby et al., 2014 [80] NCT00910962	Losmapimod*	Human Phase II	Myocardial Infarction	535 patients: no increase in adverse cardiac reactions; decreased B-type natriuretic peptide concentrations after 12 weeks.
O’Donoghue et al., 2016 [81] NCT02145468	Losmapimod*	Human Phase III	Myocardial Infarction	3503 patients: no improvements in frequency of adverse cardiac events (e.g. sudden cardiac death, recurrent MI).
Muchir et al., 2012 [82]	ARRY-371797*	Mouse	Dilated Cardiomyopathy	Improved fractional shortening; decreased dilation and αSMA gene expression; no change in Col1a1 and Col1a2 gene expression.
NCT03439514	ARRY-371797*	Human Phase III	Dilated Cardiomyopathy	Ongoing- set to be completed in 2024.
Liang et al., 2017 [84]	Verteporfin#	Mouse	Unilateral Ureteral Obstruction	Decreased renal interstitial fibrosis and number of αSMA expressing myofibroblasts.
Szeto et al., 2016 [85]	Verteporfin#	Mouse	Unilateral Ureteral Obstruction	Decreased renal interstitial fibrosis, number of αSMA expressing myofibroblasts, and Smad2/3 nuclearization.
Santos et al., 2020 [86]	Simvastatin#	Mouse	Bleomycin-induced Pulmonary Fibrosis	Decreased pulmonary interstitial fibrosis and collagen deposition.
Haak et al., 2019 [87]	Dihydrexidine#	Mouse	Bleomycin-induced Pulmonary Fibrosis Bile duct ligation	Decreased pulmonary fibrosis and αSMA fluorescent intensity. Decreased hepatic fibrosis and αSMA fluorescent intensity.

^*p38 inhibitor;

^#YAP inhibitor