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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2020 Jul 12;12(2):e1613. doi: 10.1002/wrna.1613

Figure 1:

Figure 1:

Canonical cap-dependent translation requires a m7G-capped mRNA and the eIF4F complex. A large group of viruses does not contain a cap and instead uses an IRES and a subset of translation factors for initiation.