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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: J Neuropsychiatry Clin Neurosci. 2020 Oct 22;33(1):64–71. doi: 10.1176/appi.neuropsych.20050103

TABLE 2.

Associations between cortical and subcortical β-amyloid deposition and depressive and anxiety symptoms in participants without cognitive impairment and with mild cognitive impairmenta

N Dependent variable Independent variable β SE p
Whole sample
 1,015 BDI-II score Cortical PiB-PET 0.57 0.13 <0.001
 1,015 BDI-II score Amygdala PiB-PET 0.80 0.26 0.002
 1,015 BDI-II score Striatum PiB-PET 0.69 0.18 <0.001
 1,015 BDI-II score Thalamus PiB-PET 0.61 0.24 0.011
 1,017 BAI score Cortical PiB-PET 0.34 0.13 0.011
 1,017 BAI score Amygdala PiB-PET 0.48 0.26 0.063
 1,017 BAI score Striatum PiB-PET 0.56 0.18 0.002
 1,017 BAI score Thalamus PiB-PET 0.65 0.24 0.008
Cognitively unimpaired subsample
 836 BDI-II score Cortical PiB-PET 0.38 0.15 0.013
 836 BDI-II score Amygdala PiB-PET 0.48 0.30 0.111
 836 BDI-II score Striatum PiB-PET 0.43 0.21 0.039
 836 BDI-II score Thalamus PiB-PET 0.26 0.28 0.355
 838 BAI score Cortical PiB-PET 0.23 0.15 0.124
 838 BAI score Amygdala PiB-PET 0.24 0.30 0.425
 838 BAI score Striatum PiB-PET 0.39 0.20 0.058
 838 BAI score Thalamus PiB-PET 0.48 0.28 0.086
Mild cognitive impairment subsample
 179 BDI-II score Cortical PiB-PET 0.86 0.27 0.002
 179 BDI-II score Amygdala PiB-PET 1.19 0.49 0.016
 179 BDI-II score Striatum PiB-PET 1.09 0.36 0.003
 179 BDI-II score Thalamus PiB-PET 1.17 0.49 0.017
 179 BAI score Cortical PiB-PET 0.30 0.30 0.325
 179 BAI score Amygdala PiB-PET 0.52 0.53 0.336
 179 BAI score Striatum PiB-PET 0.58 0.39 0.146
 179 BAI score Thalamus PiB-PET 0.52 0.53 0.329
a

The dependent and independent variables are presumed variables. BAI=Beck Anxiety Inventory, BDI-II=Beck Depression Inventory-II, PiB-PET=Pittsburgh Compound B positron emission tomography. β=regression coefficient, SE=standard error.