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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2020 Dec 16;31:115952. doi: 10.1016/j.bmc.2020.115952

Scheme 1.

Scheme 1.

Reagents and conditions: a) HATU, 3,4-difluoroaniline, DIPEA, DMF, 65 °C, overnight; b) ClC(O)COOEt, AlCl3, CH2Cl2, 0 °C to rt, overnight; c) i) NaOH 5%, MeOH, rt, 15 min; ii) HCl 1N; d) CDI, amine, DMF, CH2Cl2, rt, 2 h.