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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2020 Dec 16;31:115952. doi: 10.1016/j.bmc.2020.115952

Scheme 2.

Scheme 2.

Reagents and conditions: a) MeI, KOH, DMSO; b) NaOH, EtOH, 100 °C, 6 h; c) 3,4-difluoroaniline, HATU, DIPEA, DMF, 60 °C; d) ClC(O)COOEt, AlCl3, DCM, 0 °C to rt, 16 h; e) NaOH, EtOH, rt, 1 h; f) Amine, CDI, DMF, DCM, rt, 1 h.