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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Bioorg Med Chem. 2020 Dec 16;31:115952. doi: 10.1016/j.bmc.2020.115952

Scheme 3.

Scheme 3.

Reagents and conditions: a) ClC(O)COOEt, AlCl3, CH2Cl2; b) NaOH 5%, MeOH, rt, 10 min; c) CDI, amine, DMF, 3 h, rt; d) NaOH 5%, MeOH, 16 h, rt; e) 3,4-difluoroaniline, HATU, DIPEA, DMF, 16 h, rt.