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. Author manuscript; available in PMC: 2022 Feb 5.
Published in final edited form as: Behav Brain Res. 2020 Dec 3;399:113041. doi: 10.1016/j.bbr.2020.113041

Figure 1. Paclitaxel-induced sickness behaviors.

Figure 1.

A. Timeline for the assessment of chemotherapy-induced sickness behaviors. B. Chemotherapy (30 mg/kg i.p.) significantly reduced body mass by the third treatment dose, which returned to the mass of vehicle control mice by one week post-treatment. C. Chemotherapy slightly reduced the amount of food consumed during treatment. Mice that received chemotherapy consumed slightly more food 7 d post-treatment. D. Chemotherapy-treated mice exhibited similar motor coordination to mice injected with vehicle. E. Paclitaxel caused sickness behavior 3 d after a single injection and 3 d after six injections as measured by the open field test. Sickness behavior ceased by 11 d following chemotherapy. Arrows indicate days of chemotherapy/vehicle injections. *p < 0.05; **p < 0.01.