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. Author manuscript; available in PMC: 2022 Feb 5.
Published in final edited form as: Behav Brain Res. 2020 Dec 3;399:113041. doi: 10.1016/j.bbr.2020.113041

Figure 4. Exercise intervention effects on body mass, food intake, and open field test.

Figure 4.

A. Timeline of exercise intervention for paclitaxel-induced behavioral and physiological changes. B. Percent change in body mass compared to baseline. Baseline for locked and running groups was the body mass before wheels were added to cages, and baseline for chemotherapy and vehicle treatment was the body mass immediately before the first dose (10-11 days after wheels were added). C. The percent change in food intake as compared to baseline. Food intake measured on day indicated on x-axis as average per 24 h over the previous 2-4 d and calculated as a percent of baseline. D. Fatigue as measured by total locomotion over 15 min in an open-field arena. Total wheel revolutions were used as a covariate in all analyses to control for unequal exercise performance between vehicle and chemotherapy groups. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.