Table 3.

Gene-based burden association tests of candidate genes in 789 ET cases and 770 healthy individuals.

Gene name	Sample size	N of variants*	Total MAC†	Beta	P-value	Wald statistic
CCDC183	1559	15	48	−0.2842	0.8599	−1.0798
MMP10	1559	13	37	0.1209	0.3589	0.3615
GPR151	1559	13	19	−0.1075	0.5964	−0.2442
MS4A14	1559	16	43	0.2237	0.2317	0.7332
GEMIN5	1559	31	138	−0.2798	0.9512	−1.6564

Key: ET, Essential tremor; MAC, minor allele count; N, number.

Only exonic deleterious variants (missense, non-sense SNVs) with a minor allele frequency below 1% in gnomAD non-Finnish Europeans exomes were used for the analysis.

Bonferroni corrected p-value threshold for MAF<1% is 0.01.

^*The number of variants in each group is adjusted for specified MAF; in this case, below 0.01.

^†The total minor allele count (MAC) in a group adjusted for mode of inheritance.