. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: Biochim Biophys Acta Rev Cancer. 2020 Dec 26;1875(1):188498. doi: 10.1016/j.bbcan.2020.188498

Table 2:

Onco-suppressive functions of H3K9 methyl

Anti-Tumor activity

H3K9 methyl transferase	Cancer type	Biological process affected

G9a	Lung carcinoma [86]	-
G9a/GLP	Glioma [130]	Suppression of self-renewal genes [130]
	Hematological malignancies [117]	-

SETDB1	Lung carcinoma [131,132]	Suppressor of metastasis [133]
	Breast carcinoma [80]	Suppressor of metastasis [80]
	Hematological malignancies [117,134]	Induced differentiation and suppression of self-renewal genes [134]

SUV39H1	Breast carcinoma [75]	Suppression of cell cycle gene [75]
	Ovarian and cervical carcinoma [135]	-
	Parathyroid carcinoma [136]	Suppression of cell cycle gene [136]
	Hematological malignancies [52,137] Rhabdomyosarcoma [138]	Induced apoptosis[137]

SUV39H2	Lung carcinoma [139]	Induced cell cycle arrest [139]

- Further evaluation required