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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Biomaterials. 2020 Nov 23;268:120528. doi: 10.1016/j.biomaterials.2020.120528

Figure 2. si-NPs stimulate PAF release, as measured through PAF-AH exhaustion, and do not directly agonize the PAF receptor.

Figure 2.

A) Mice injected with si-NPs display decreased PAF-AH activity in blood samples 15 minutes after injection. B) The si-NP PMPC corona comprises zwitterionic phosphorylcholine that contains similar structure to PAF. C) PAF activates the PAFR through a mechanism that is inhibited by ABT-491 pre-treatment in Chem-1 cells overexpressing PAFR, but PMPC-based si-NPs do not (** p<0.01).