. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: Expert Opin Ther Targets. 2020 Nov 23;25(1):63–73. doi: 10.1080/14728222.2021.1849145

Table 1:

Function of STAT3 Domains.

Domain	Function [14, 18, 101]
NH2	Formation of higher order complexes
CCD	Protein-protein interaction
	Receptor binding
	Nuclear export
DBD	Recognition of GAS
DBD	Nuclear transport
LD	Interaction with specific tyrosine-phosphorylated residues of activated STAT3
LD	Formation of STAT3 homo or heterodimers
SH2	Formation of STAT3 dimerization through intramolecular phosphorylated tyrosine- SH2 interaction
SH2	Recruitment of specific receptors
Transactivation domain	Regulatory phosphorylation

NH2: (Amino) N-terminal domain; CCD: Coiled-coiled domain; DBD: DNA binding domain; LD: Linker domain; SH2: Src homology 2 domain; GAS: γ-activated sequences.