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PARylation and modes of PARP1 interactions. Upon activation, PARP1 can influence protein functions through either covalent PARylation of target proteins or through non‐covalent interactions after autoPARylation. PAR associates with RNA binding domains where it competes for binding with target RNA. PARG then degrades PAR to mono ADP‐ribose, which can then be further digested by ADP‐ribosyl hydrolase 3 or TARG (not shown)
