Figure 2. Prevalence and severity of disturbance-associated seizure-like events in R59X/+ females increases with age.
(A) Percentage of Cdkl5RS9X/+ (R59X/+) females presenting with any seizure-like event (Racine Stages 1 to 5; black line) and percentage of R59X/+ females presenting with at least one severe seizure-like event (Racine Stages 3 to 5; blue line) between 12 weeks to 45 weeks of age (n=20). Median age of onset for second observed seizure-like event was 28 weeks; median age of onset for severe seizure-like events was 47 weeks of age. (B) Percentage of R59X/+ females observed having at least one seizure-like event (Racine Stages 1 to 5; black line) and percentage of R59X/+ females observed having at least one severe seizure-like event (Racine Stages 3 to 5; blue line) any given week between 12 to 52 weeks of age (n=25).
(C) Event record of 20 Cdkl5RS9X/+ females observed from 12 weeks to 45 weeks of age. Gray: no seizure-like events observed during that week. Blue: at least one myoclonic seizure-like event (Racine Stages 1 to 2), but no severe seizure-like event, observed during that week. Black: at least one severe seizure-like event (Racine Stages 3 to 5) observed during that week.