Table 1.

Lactate dehydrogenase (LDH) activity in cell culture medium presented in % of control after exposure to ALN, OME and ALN + OME.

Osteoblasts
Day	Alendronate 5 μM	P-value	Omeprazole 1 μM	P-value	Alendronate + omeprazole	P-value
1	100.5 ± 2.6	0.872	95.8 ± 2.1	0.140	99.1 ± 0.9	0.492
3	103.4 ± 2.9	0.378	93.3 ± 3.4	0.150	98.1 ± 3.6	0.658

Fibroblasts
Day	Alendronate 5 μM	P-value	Omeprazole 1 μM	P-value	Alendronate + omeprazole	P-value
1	107.9 ± 2.6	0.070	102.4 ± 2.2	0.442	98.8 ± 1.2	0.609
3	99.4 ± 3.0	0.866	98.9 ± 3.5	0.770	101.1 ± 1.7	0.580

The effect was measured after 1 and 3 days of incubation with 5 μM ALN, 1 μM OME and ALN + OME.