Fig. 1.

a Systematic structures of SARS-nCoV-2 genome organization and identified antigenic epitopes. A ~ 72 nucleotides of long chain flank the SARS-nCoV-2 genome at the 5′ end and a poly(A) tail at the 3′ end. Many other open reading frames (ORFs) relating to viral structural components (S, E, M and N proteins) and companion genes (ORF 1a, 1b, 3a, 6, 7a, 7b, 8 and 10) were identified, all of which reflect different colors. The antigen-presenting epitope peptide sequence regions and ranges of each protein have been identified in various colors. b Library design of antigenic epitope peptides for β-cell/T cell recognition. SARS-nCoV-2 antigen epitope model selection based on score feature to infer peptide antigens and homologous peptide antigens through structural templates based on score Z value (Jz) < v3, along with experimental peptides and full pathogen genome databases. The preference of epitopes is known as a β-cell/T cell displaying various colors through prioritization