Table 1.
Distribution of poor prognostic indicators among DR – TB patients.
| Number (%)§ | Number with poor prognostic indicator at treatment initiation (%)§ | |
|---|---|---|
| Poor prognostic indicator | ||
| Hepatic dysfunction | 780 (84.1) | 151 (31.1) |
| HIV co-infection | 666 (59.4) | 489 (98.4) |
| Low baseline body mass index | 276 (58.3) | 276 (58.4) |
| Hearing loss | 359 (44.7) | 66 (24.8) |
| Alcohol use | 313 (38.4) | 313 (100.0) |
| Diabetes | 48 (31.8) | 48 (100.00 |
| Elevated creatinine | 279 (29.9) | 31 (18.1) |
| Cigarette smoking | 155 (19.0) | 155 (100.0) |
| Severe Anaemia | 115 (11.7) | 49 (59.8) |
| Psychiatric symptoms or mental illness | 69 (6.2) | 19 (32.2) |
| Pregnancy | 18 (4.4)† | 6 (54.6) |
| Previous exposure to second line drugs | 30 (2.7) | 30 (100.0) |
| Cancer | 17 (1.5) | 5 (55.6) |
| Resistance to fluoroquinolones and/or injectable aminoglycoside* | 14 (1.2) | 14 (100.0) |
| Heart failure | 5 (0.45) | 0 (0.0) |
| Number of poor prognostic indicators per patient | ||
| 1 | 197 (17.6) | |
| 2 | 329 (29.3) | |
| 3 | 280 (25.0) | |
| 4 | 174 (15.5) | |
| 5 | 88 (7.8) | |
| ≥6 | 54 (4.8) |
*Includes 2 patients with extensively drug resistant tuberculosis, §the denominator is the participants for whom data were available for a given poor prognostic indicator, †percentage is calculated out of the 413 females in the study.