Table 3.

Predictors of treatment success among DR – TB patients with poor prognostic indicators.

	Univariate analysis				Multivariable analysis
Characteristic	OR	95% CI		p-value	OR	95% CI		p-value
Type of Treatment Site
National Referral Hospital	1
Regional Referral Hospital	1.55	1.16	2.06	0.003
District Hospital	2.78	1.71	4.53	<0.001
Residence
Rural	1
Urban	0.68	0.52	0.89	0.005
Age (years)
<15	1
15–34	0.27	0.08	0.93	0.037
35–60	0.34	0.10	1.13	0.079
>60	0.29	0.08	1.08	0.065
Alcohol use
None	1
Yes	0.64	0.46	0.88	0.007
Cigarette smoking
None	1
Yes	0.55	0.38	0.80	0.002
HIV status
Positive	1
Negative	2.22	1.70	2.95	<0.001
Anaemia
Normal haemoglobin level	1				1
Mild	0.59	0.40	0.87	0.007	0.57	0.39	0.84	0.004
Moderate	0.18	0.12	0.27	<0.001	0.18	0.12	0.26	<0.001
Severe	0.09	0.05	0.17	<0.001	0.09	0.05	0.17	<0.001
Baseline body mass index	1.09	1.02	1.16	0.016
Cancer
Yes	1
No	2.92	1.12	7.65	0.029
Ethambutol resistance
Yes	1
No	0.69	0.48	0.98	0.038
Streptomycin resistance
Yes	1
No	0.70	0.50	0.99	0.042
No. of poor prognostic indicators	0.83	0.76	0.91	<0.001
Previous exposure to SLDs
Yes	0.22	0.10	0.46	<0.001	0.19	0.08	0.48	<0.001
No	1				1
No. of drugs a patient was resistant to	1.13	1.01	1.27	0.041
Drugs in the treatment regimen
Levofloxacin
No	1
Yes	0.66	0.45	0.95	0.025
Moxifloxacin
No	1
Yes	1.54	1.06	2.22	0.022
Capreomycin
No	1
Yes	1.64	1.08	2.47	0.019
Clofazimine
No	1
Yes	1.57	1.09	2.25	0.015
High-dose Isoniazid
No	1
Yes	1.66	1.15	2.41	0.008
Ethambutol
No	1
Yes	1.64	1.15	2.36	0.007
Number of drugs in regimen
<5	1
≥5	1.74	1.32	2.28	<0.001

OR – odds ratio, CI – confidence interval, SLDs – Second line drugs.