Table 4.
Predictors of mortality among DR – TB patients with poor prognostic indicators.
| Univariate analysis |
Multivariable analysis |
|||||||
|---|---|---|---|---|---|---|---|---|
| Characteristic | HR | 95% CI | p-value | HR | 95% CI | p-value | ||
| Type of Treatment Site | ||||||||
| National Referral Hospital | 1 | |||||||
| Regional Referral Hospital | 0.89 | 0.66 | 1.20 | 0.444 | ||||
| District Hospital | 0.34 | 0.19 | 0.62 | <0.001 | ||||
| Year of enrolment | ||||||||
| ≤ 2013 | 1 | |||||||
| 2014 | 0.96 | 0.49 | 1.91 | 0.916 | ||||
| 2015 | 1.17 | 0.64 | 2.18 | 0.601 | ||||
| 2016 | 1.72 | 0.99 | 3.01 | 0.055 | ||||
| 2017 | 0.94 | 0.52 | 1.69 | 0.843 | ||||
| 2018 | 1.08 | 0.59 | 2.02 | 0.791 | ||||
| 2019 | 2.82 | 1.47 | 5.39 | 0.002 | ||||
| Alcohol use | ||||||||
| None | 1 | |||||||
| Yes | 1.75 | 1.24 | 2.46 | 0.001 | ||||
| No. of poor prognostic indicators | 1.28 | 1.18 | 1.40 | <0.001 | 1.62 | 1.30 | 2.01 | <0.001 |
| Cigarette smoking | ||||||||
| None | 1 | |||||||
| Yes | 2.15 | 1.49 | 3.09 | <0.001 | ||||
| HIV status | ||||||||
| Positive | 1 | |||||||
| Negative | 0.47 | 0.35 | 0.64 | <0.001 | ||||
| Anaemia | ||||||||
| Normal haemoglobin | 1 | |||||||
| Mild | 1.94 | 1.20 | 3.15 | <0.001 | ||||
| Moderate | 6.82 | 4.44 | 10.50 | <0.001 | ||||
| Severe | 13.19 | 7.97 | 21.84 | 0.007 | ||||
| Cancer | ||||||||
| No | 1 | |||||||
| Yes | 3.55 | 1.82 | 6.93 | <0.001 | ||||
| Streptomycin resistance | ||||||||
| No | 1 | |||||||
| Yes | 0.69 | 0.48 | 1.00 | 0.049 | ||||
| Body mass index | ||||||||
| <18.5 | 1 | |||||||
| 18.5–24.9 | 0.60 | 0.36 | 0.99 | 0.045 | ||||
| 25.0–29.9 | 0.31 | 0.04 | 2.27 | 0.251 | ||||
| No. of drugs a patient was resistant to | 0.87 | 0.76 | 0.99 | 0.033 | ||||
| Number of drugs in regimen | ||||||||
| <5 | 1 | |||||||
| ≥5 | 0.70 | 0.52 | 0.93 | 0.013 | ||||
| Month of culture conversion | 0.85 | 0.73 | 0.99 | 0.033 | ||||
HR – hazard ratio, CI – confidence interval.