Table 3.
Summary of Analyses in Patients Stratified by Histologic Findings
| Cohort | Cohort Size | No. of Patients Undergoing Lobectomy | No. of Patients Undergoing Segmentectomy | Overall P Value of Interaction Between Tumor Size and Type of Surgery |
|---|---|---|---|---|
| Adenocarcinoma | ||||
| Overall cohort | 86,573 | 81,926 | 4,647 | < .001 |
| Lepidic subgroup | 18,687 | 17,468 | 1,219 | .03 |
| Papillary subgroup | 2,099 | 1,990 | 109 | .61 |
| Mucinous subgroup | 7,739 | 7,273 | 466 | .21 |
| Acinar subgroup | 4,210 | 3,928 | 282 | .67 |
| pN0 subgroup | 66,303 | 62,784 | 3,519 | .007 |
| Squamous cell carcinoma | ||||
| Overall cohort | 36,613 | 34,747 | 1,866 | .03 |
| pN0 subgroup | 28,952 | 27,521 | 1,431 | < .001 |
| Neuroendocrine tumors | ||||
| Large cell | 3,240 | 3,076 | 164 | .27 |
| Carcinoid | 6,927 | 6,491 | 436 | .61 |
Each row represents a unique multivariate Cox proportional hazards regression. The models were adjusted for age, sex, race and ethnicity, year of diagnosis, Charlson-Deyo score, insurance status, treatment at an academic center, annualized center surgical volume, identity of lobe, tumor size, type of surgery, and an interaction term between tumor size and type of surgery.