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. 2021 Jan 8;10:595533. doi: 10.3389/fonc.2020.595533

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Copyright © 2021 Xia, Chen, Yang, Zhu, Zhang, Yin, Hong, Chen, Chen and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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lncRNA-PAICC requires miR-141-3p and miR-27a-3p to promote proliferation and metastasis and activate the Hippo-YAP pathway in ICC cells. (A) YAP1 mRNA (upper panel) and corresponding protein (lower panel) levels in stable HUCCT-1 and QBC-939 cell lines after transfection of the indicated miR-27a-3p inhibitors or mimics. Data are mean ± SD. (B) YAP1 mRNA (upper panel) and corresponding protein (lower panel) levels in stable HUCCT-1 and QBC-939 cell lines after transfection of the indicated miR-141-3p inhibitors or mimics. Data are mean ± SD. (C) Transwell migration and invasion assays of lncRNA-PAICC-silenced HUCCT-1 cells treated with the indicated microRNA inhibitors. Data are mean ± SD. *P < 0.05. All the experiments were repeated three times.